| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 9
| Issue : 4 | Page : 171-176 |
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Association of leukotrichia in vitiligo and Asp148Glu polymorphism of apurinic/apyrimidinic endonuclease 1
A Fatih Aydin1, İkbal Esen Aydıngöz2, Semra Doğru-Abbasoğlu1, Pervin Vural1, Müjdat Uysal1
1 Department of Biochemistry, Faculty of Medicine, Istanbul University, Istanbul, Turkey
2 Department of Dermatology, School of Medicine, Acıbadem University, Istanbul, Turkey
Correspondence Address:
İkbal Esen Aydıngöz
Department of Dermatology, School of Medicine, Acibadem University, Inonu Caddesi Okur Sokak No: 20, Kozyatağı 34742, Istanbul
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijt.ijt_4_17
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Background: Oxidative stress and increased DNA damage have been implicated in the etiopathogenesis of vitiligo. Oxidative DNA damage is mainly repaired by the base excision repair (BER) pathway. Aim: We sought to determine whether polymorphisms in DNA repair genes may have a role in the pathogenesis of vitiligo. Materials and Methods: We conducted a study including 100 patients with vitiligo and age- and sex-matched 193 control subjects to examine the role of single-nucleotide polymorphisms of BER genes, human 8-oxoG DNA N-glycosylase 1 (codon 326), apurinic/apyrimidinic endonuclease 1 (APE1) (codon 148), and X-ray repair cross-complementing group 1 (codon 399) as risk factors for vitiligo. These polymorphisms were determined by quantitative real-time polymerase chain reaction and melting curve analysis. Results: No significant association was observed between the variant alleles of studied genes and vitiligo. Conclusion: However, we showed that the presence of APE1 148Glu variant allele is associated with leukotrichia. This preliminary study suggests that APE1 (codon 148) polymorphism may play a role in vitiligo pathogenesis. |
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