International Journal of Trichology International Journal of Trichology
 Print this page Email this page Small font sizeDefault font sizeIncrease font size
  Home | About IJT | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submission | Subscribe | Advertise | Contact us | Login   
Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 188-190

Clinical experience with oral tofacitinib in a patient with alopecia areata universalis and rheumatoid arthritis

Department of Dermatology, Federal University of Paraná, Curitiba, Paraná, Brazil

Correspondence Address:
Dr. Daniele Tiemi Abe
Rua General Carneiro, 181 - Alto da Gloria, Curitiba, Parana
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijt.ijt_107_20

Rights and Permissions

Alopecia areata (AA) is a chronic and autoimmune disease frequently characterized by a challenge management between dermatologists. At present, JAK-inhibitors have demonstrated encouraging results in AA treatment. Therefore, this study reports a case of alopecia universalis in a patient with rheumatoid arthritis (RA), whose methotrexate therapy shown unsatisfactory response in RA control. After the introduction of 10 mg (oral route) per day of tofacitinib, a JAK-inhibitor, an improvement of almost 50% in severity alopecia tool score occurred with maintained response even after 3 months of medication suspension. From this time, we corroborate the effectiveness of JAK-inhibitors presented in the scientific literature. In addition, we inquiry the real impact of methotrexate on JAK-start signaling inhibition in AA pathophysiology.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded36    
    Comments [Add]    
    Cited by others 2    

Recommend this journal