utd_medknow
International Journal of Trichology International Journal of Trichology
 Print this page Email this page Small font sizeDefault font sizeIncrease font size
 
 
  Home | About IJT | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Online submission | Subscribe | Advertise | Contact us | Login   
 


 
 Table of Contents  
LETTER TO EDITOR
Year : 2022  |  Volume : 14  |  Issue : 4  |  Page : 147-149  

Male frontal fibrosing alopecia with generalized body hair loss


1 Delhi Dermatology Group - Kubba Skin Clinic, New Delhi, India
2 Dermatology Practice, Delhi Dermpath Lab, New Delhi, India

Date of Submission06-May-2020
Date of Decision23-Jul-2020
Date of Acceptance12-Jan-2021
Date of Web Publication16-Jul-2022

Correspondence Address:
Aashim Singh
10, Aradhana Enclave, Ring Road on RK Puram, New Delhi - 110 066
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijt.ijt_66_20

Rights and Permissions

How to cite this article:
Singh A, Arshdeep, Batrani M, Kubba A. Male frontal fibrosing alopecia with generalized body hair loss. Int J Trichol 2022;14:147-9

How to cite this URL:
Singh A, Arshdeep, Batrani M, Kubba A. Male frontal fibrosing alopecia with generalized body hair loss. Int J Trichol [serial online] 2022 [cited 2022 Aug 14];14:147-9. Available from: https://www.ijtrichology.com/text.asp?2022/14/4/147/351243



Sir,

Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris (LPP), commonly involving the fronto-temporal scalp. FFA presents most commonly in postmenopausal women and is rarely reported in males.[1],[2] Body hair loss has been described earlier in FFA, mainly as clinically nonscarring loss of eyebrows, axillary and pubic hair and less commonly truncal and limbal hair loss. Recent literature has shown that body hair loss in FFA also reveals histological follicular scarring, thereby confirming that LPP is a generalized disease process.[1],[3],[4] Herein, we describe a case of FFA in a male patient with generalized body hair loss.

A 37-year-old male of South-East Asian origin presented with receding of frontal hairline along with loss of eyebrows and eyelashes [Figure 1]a and [Figure 1]b. He had also noticed hair loss over the body since childhood, which was gradually progressive to involve the whole body [Figure 1]c, [Figure 1]d, [Figure 1]e. Family history and systemic examination were unremarkable. Frontal hairline recession of approximately 8 cm from the glabella was noted along with “lonely hair” sign. Hair loss was seen in the frontal, temporal as well as occipital hairline in a band-like pattern, with follicular erythema on the residual frontal hairline. Loss of lateral two-thirds of eyebrows and patchy loss of eyelash cilia with mild erythema over the eyelid margins was noted [Figure 1]a. Generalized body hair loss involving axillae, pubic hair, trunk and limbs was observed, sparing few areas on the legs. While truncal hair alopecia including axillary and pubic hair, was observed as clinically nonscarring [Figure 1]c and [Figure 1]d; discrete follicular atrophic scarring was present over bilateral thighs, legs, and arms [Figure 1]e.
Figure 1: (a) Clinical photograph of patient showing fronto-temporal hairline recession along with loss of eyebrows and eyelashes. (b) Loss of side burns in the patient. (c) Loss of body hair on chest in a clinically non-scarring presentation. (d) Loss of axillary hair in a clinically non-scarring presentation. (e) Loss of body hair on legs with discrete follicular atrophic scars

Click here to view


Trichoscopic examination of scalp from frontal hairline showed loss of follicular openings and absence of vellus hairs along the hair margin. Peripilar casts and perifollicular erythema were seen at the level of hair shaft emergence on scalp hairline and eyebrows and eyelashes [Figure 2]a and [Figure 2]b. Dermoscopy of limbs showed loss of body hair with discrete follicular scars and subtle peripilar casts on the residual body hair [Figure 2]c.
Figure 2: (a) Trichoscopy of the frontal hairline showing absence of vellus hairs and scarring along the hair margin with peripilar casts and perifollicular erythema (Fotofinder videodermoscope, ×20 polarized). The ink-marked site was chosen for biopsy. (b) Dermoscopy of eyelid margin showing loss of eyelashes, erythema and subtle peripilar cast on the remaining eyelash (Fotofinder videodermoscope, ×20 polarized with ultrasound gel as contact medium). (c) Dermoscopy of leg showing loss of follicular openings and subtle peripilar cast on residual body hair (Fotofinder videodermoscope, ×20 polarized)

Click here to view


A trichoscopy-guided 4 mm punch biopsy was taken from the residual frontal hairline of the scalp. Histopathological examination showed follicular scars replacing occasional follicular units. The intact follicular units show partial loss of sebaceous glands and perifollicular lamellar fibrosis with surrounding lymphocytic infiltrate along isthmus and infundibular region. Lymphocytes were seen infiltrating outer follicular epithelium showing vacuolization and multiple apoptotic keratinocytes, thereby confirming the histological diagnosis of LPP [Figure 3]a and [Figure 3]b. Biopsy was not undertaken from body hair, in the absence of any active skin lesion. A diagnosis of FFA with generalized involvement of body hair was made based on clinical, dermoscopic and histopathological examination. The patient was started on hydroxychloroquine 200 mg twice daily, finasteride 1 mg once daily, and topical tacrolimus.
Figure 3: (a) Transverse section of scalp biopsy showing follicular scar, perifollicular lamellar fibrosis and surrounding lymphocytic infiltrate, (H and E, ×40). (b) Lichenoid pathology seen as lymphocytes infiltrating outer follicular epithelium showing vacuolization and multiple apoptotic keratinocytes, (H and E, ×200)

Click here to view


FFA is usually seen in women of the older age group, however, our patient started developing his disease in childhood. There are only four reported cases in the literature in the pediatric age group who were all girls.[5] The prevalence of FFA in males is quite low and has not been reported in Asians.[2] It may be under-recognized in males. FFA needs to be differentiated from androgenetic alopecia (AGA) by trichoscopic examination, which reveals the absence of vellus hairs in the former, as also seen in our case. FFA has selective predilection for vellus hair while they are spared in AGA and clinical scarring is evident in FFA.

The most striking feature in the index case is the loss of body hair associated with clinical atrophic scarring, which has not been described earlier in literature. Dermoscopy highlighted the atrophic follicular scars but the absence of histology is a limitation in our case. Previous reports have always shown clinically nonscarring alopecia of body hair, even though histologically a lichenoid pathology and scarring process has been documented, thereby conforming that LPP is a generalized disease process.[1],[3],[4],[6] Hence, our case is unique in the clinical presentation of scarring alopecia of body hair in association with FFA.

Furthermore, in our case, FFA was quite extensive owing to the involvement of the occipital scalp in a band-like fashion with eyebrow and eyelash loss as well. Occipital involvement has been reported in 15% cases (48 women and only 4 men) in a multicentre study involving 355 total patients, reflecting a more severe disease. Furthermore, body hair involvement and eyelash loss are associated with the disease severity of FFA.[6]

To conclude, this case of FFA in an Asian male with generalized body hair involvement in the form of clinically scarring alopecia on the limbs depicts a severe generalized disease and extends the spectrum of body hair involvement in FFA. Trichoscopy is a valuable tool for differentiating FFA from AGA and delineating body hair involvement in FFA.[4]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Chen W, Kigitsidou E, Prucha H, Ring J, Andres C. Male frontal fibrosing alopecia with generalised hair loss. Australas J Dermatol 2014;55:e37-9.  Back to cited text no. 1
    
2.
Tolkachjov SN, Chaudhry HM, Camilleri MJ, Torgerson RR. Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases. J Am Acad Dermatol 2017;77:683-9000.  Back to cited text no. 2
    
3.
Armenores P, Shirato K, Reid C, Sidhu S. Frontal fibrosing alopecia associated with generalized hair loss. Australas J Dermatol 2010;51:183-5.  Back to cited text no. 3
    
4.
Arshdeep, Batrani M, Kubba A, Kubba R. Lichen planopilaris beyond scalp: A case series with dermoscopy-histopathology correlation. Int J Dermatol 2018;57:e127-e131.  Back to cited text no. 4
    
5.
Atarguine H, Hocar O, Hamdaoui A, Akhdari N, Amal S. Frontal fibrosing alopecia: Report on three pediatric cases. Arch Pediatr 2016;23:832-5.  Back to cited text no. 5
    
6.
Vañó-Galván S, Molina-Ruiz AM, Serrano-Falcón C, Arias-Santiago S, Rodrigues-Barata AR, Garnacho-Saucedo G, et al. Frontal fibrosing alopecia: A multicenter review of 355 patients. J Am Acad Dermatol 2014;70:670-8.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References
    Article Figures

 Article Access Statistics
    Viewed206    
    Printed4    
    Emailed0    
    PDF Downloaded2    
    Comments [Add]    

Recommend this journal