International Journal of Trichology

CASE REPORT
Year
: 2020  |  Volume : 12  |  Issue : 3  |  Page : 129--131

Scanning electron microscopy of subclinical gefitinib-induced hair changes


Hiram Larangeira de Almeida1, Debora Sarzi Sartori3, Antônia Larangeira de Almeida2, Caroline Pires Ruas3, Gustavo Zerwes4 
1 Department of Dermatology, Catholic and Federal University of Pelotas; Post-Graduation Program in Health Sciences, Catholic University of Pelotas, Rio Grande, Brazil
2 Dermatology League, Federal University of Pelotas, Rio Grande, Brazil
3 Electron Microscopy Center, Federal University of Rio Grande, Rio Grande, Brazil
4 Center for Oncology - Ceron, Pelotas, Brazil

Correspondence Address:
Dr. Hiram Larangeira de Almeida
Rua Gonçalves Chaves 373, Pelotas
Brazil

Oral inhibitors of epidermal growth factor receptor may have a wide range of cutaneous manifestations. Hair manifestations are observed in 10%–20% of the patients. At the ultrastructural level erlotinib-induced hair changes were already described as acquired pili torti et canaliculi. We examined a 78-year-old female patient, with lung carcinoma, taking gefitinib for 15 months. The treatment has no side effects with good tolerance and tumor response. Although the patient had not observed any change on the hairs under the therapy, some specimens were obtained to be examined in natura with scanning electron microscopy. Under low magnification incipient grooving was observed on the hair surface, tortions or angulations of the hair shaft were not found. With higher magnifications the surface grooving was even more evident. Our findings show that gefitinib may cause subclinical hair changes, similar to those described at the ultrastructural level with erlotinib.


How to cite this article:
de Almeida HL, Sartori DS, de Almeida AL, Ruas CP, Zerwes G. Scanning electron microscopy of subclinical gefitinib-induced hair changes.Int J Trichol 2020;12:129-131


How to cite this URL:
de Almeida HL, Sartori DS, de Almeida AL, Ruas CP, Zerwes G. Scanning electron microscopy of subclinical gefitinib-induced hair changes. Int J Trichol [serial online] 2020 [cited 2022 Dec 3 ];12:129-131
Available from: https://www.ijtrichology.com/article.asp?issn=0974-7753;year=2020;volume=12;issue=3;spage=129;epage=131;aulast=de;type=0