International Journal of Trichology International Journal of Trichology
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   2009| January-June  | Volume 1 | Issue 1  
    Online since June 6, 2009

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Oxidative stress in ageing of hair
Ralph M Trueb
January-June 2009, 1(1):6-14
DOI:10.4103/0974-7753.51923  PMID:20805969
Experimental evidence supports the hypothesis that oxidative stress plays a major role in the ageing process. Reactive oxygen species are generated by a multitude of endogenous and environmental challenges. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage cellular structural membranes, lipids, proteins, and DNA. The body possesses endogenous defence mechanisms, such as antioxidative enzymes and non-enzymatic antioxidative molecules, protecting it from free radicals by reducing and neutralizing them. With age, the production of free radicals increases, while the endogenous defence mechanisms decrease. This imbalance leads to the progressive damage of cellular structures, presumably resulting in the ageing phenotype. Ageing of hair manifests as decrease of melanocyte function or graying, and decrease in hair production or alopecia. There is circumstantial evidence that oxidative stress may be a pivotal mechanism contributing to hair graying and hair loss. New insights into the role and prevention of oxidative stress could open new strategies for intervention and reversal of the hair graying process and age-dependent alopecia.
  38 18,322 663
Finasteride induced gynecomastia: Case report and review of the literature
Yuval Ramot, Tali Czarnowicki, Abraham Zlotogorski
January-June 2009, 1(1):27-29
DOI:10.4103/0974-7753.51930  PMID:20805972
Finasteride (1 mg/day) is widely utilized by dermatologists for the treatment of androgenetic alopecia. Although enjoying a relatively good safety profile, several sex-related adverse effects have been reported with this drug. Here we report two cases of gynecomastia, one of them bilateral, caused by Propecia prescribed for the treatment of androgenetic alopecia. Although relatively rare, physicians should be aware of this side effect and inform their patients when prescribing this medication.
  17 9,116 261
Tonsuring: Myths and facts
Kaliaperumal Karthikeyan
January-June 2009, 1(1):33-34
DOI:10.4103/0974-7753.51927  PMID:20805974
  4 6,060 189
Dealing wildlife offences in India: Role of the hair as physical evidence
Vivek Sahajpal, SP Goyal, Kumudbala Singh, Vinod Thakur
January-June 2009, 1(1):18-26
DOI:10.4103/0974-7753.51928  PMID:20805971
India is known for its rich biodiversity, with a wide variety of wild floral and faunal species. This wildlife treasure of ours faces the threat of extinction due to rampant poaching and illegal trade. With most of the wildlife offence cases related to mammals having hair as physical evidence, it becomes imperative to use this evidence in the best possible way for wildlife crime investigation. We discuss the value of hair evidence with special reference to species characterization/identification using microscopic hair characteristics, keratin patterns, and mitochondrial DNA typing. The relevance of the techniques with respect to Indian scenario is specially taken care of and microscopic hair characteristics of one of the highly endangered species along with its keratin pattern are described. Finally, the use of mitochondrial DNA for species identification is also discussed.
  3 5,110 323
Neurodegenerative disorders with hair abnormalities: An emergency room consultation for dermatologists
Arun C Inamadar, Aparna Palit
January-June 2009, 1(1):30-32
DOI:10.4103/0974-7753.51929  PMID:20805973
Menke's syndrome and Elejalde disease are the two neurodegenerative disorders of dermatological interest. These patients present with characteristic hair changes which may be of diagnostic value in resource-poor setup where facilities for specific genetic analysis are not available. Simple light microscopic examination of hair may be a helpful diagnostic tool to pick up such cases.
  2 3,751 119
Spangled hair in siblings
Sundaram Murugusundram
January-June 2009, 1(1):35-36
DOI:10.4103/0974-7753.51925  PMID:20805975
  2 2,331 106
Why another journal?
Patrick Yesudian
January-June 2009, 1(1):1-1
DOI:10.4103/0974-7753.51913  PMID:20805965
  2 2,426 162
Hair abnormalities in genetic disorders of junctions
Paul D Yesudian
January-June 2009, 1(1):15-17
DOI:10.4103/0974-7753.51926  PMID:20805970
The desmosomes form the basis of intercellular support structure within the epidermis. However, various junctions, including gap junctions, adherens junctions, and tight junctions play an important part in the intercellular bridges that are vital for cell-cell interactions and structural stability. Numerous mutations can affect the genetic structure that make up these junctions and in turn cause disease. Most of these conditions have hair abnormalities and this article will briefly elucidate the various manifestations in the hair. As these junctional elements are found in other organs like the heart, liver, and eye, there could be serious systemic associations along with the hair changes.
  2 3,325 196
Some thoughts: Scattered hair and there!
Shyam B Verma
January-June 2009, 1(1):4-5
DOI:10.4103/0974-7753.51921  PMID:20805968
  - 2,519 127
EHRS 2009
EHRS 2009 program

January-June 2009, 1(1):40-41
  - 1,265 89
Opening lecture

January-June 2009, 1(1):42-42
  - 1,365 72
Tricho-philosophical morning dew

January-June 2009, 1(1):43-43
  - 1,316 64
John Ebling lecture

January-June 2009, 1(1):44-44
  - 1,428 69
Oral presentations

January-June 2009, 1(1):45-59
  - 1,325 130

January-June 2009, 1(1):60-74
  - 1,342 134
Guest editorial - Fourteenth European hair research society annual meeting 2009, Graz, Austria
Daisy Kopera
January-June 2009, 1(1):39-39
  - 1,997 75
Twenty years of European hair research society
Ralph M Trueb
January-June 2009, 1(1):2-2
DOI:10.4103/0974-7753.51916  PMID:20805966
  - 2,369 171
Journey through the world of hair
Sundaram Murugusundram
January-June 2009, 1(1):3-3
DOI:10.4103/0974-7753.51918  PMID:20805967
  - 2,522 209